Waterhemp is quickly becoming the #1 weed issue for Michigan soybean farmers. Resistance to glyphosate (Group 9) and the ALS-inhibiting herbicides (Group 2) is found in almost all waterhemp populations identified in Michigan. Additionally, Group 14 (Flexstar and Cobra)-resistant and Group 5 (triazine)-resistant populations have also been identified in Michigan. These resistance issues make management of waterhemp a high priority. As waterhemp problems continue to spread throughout Michigan and resistance issues increase, new herbicide-resistant soybean technologies will be important for management of this weed. LibertyLink GT27, Enlist, and XtendFlex soybean are new soybean technologies that will provide farmers with new potential options to manage multiple-resistant waterhemp. Developing and identifying which management strategies work with these new herbicide-resistant soybean traits is needed. During the 2020 season, we conducted research that examined various weed management strategies with each of these soybean traits. As waterhemp issues continue to spread and these new soybean traits become more prevalent in Michigan soybean fields it will be important to continue to conduct research that will develop and strengthen our recommendations for waterhemp control with the following objectives. 1) Develop and evaluate waterhemp control programs utilizing the LibertyLink GT27 soybean technology. 2) Evaluate various weed control programs in Enlist soybean for waterhemp control. 3) Compare various weed control programs that use dicamba (XtendiMax)-based, glufosinate (Liberty)-based, and various combinations of these herbicides to standard waterhemp control programs in XtendFlex soybean. 4) Provide new information on the cost-effective management of herbicide-resistant waterhemp to Michigan soybean growers. This research is important to provide effective management strategies to Michigan soybean farmers about this economically troublesome weed.