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Soybean cyst nematode (SCN) (Heterodera glycines) is consistently ranked among the top destructive soybean pathogens across the United States and is the most significant nematode pest affecting soybeans in Delaware and the Eastern Shore of Maryland. SCN has been present in Delaware since 1979 prompting growers to rely on resistant varieties, primarily using the PI88788 resistance source. However, additional control strategies are needed as SCN populations have begun reproducing readily on these once resistant cultivars. A five-replication field trial was conducted in 2020 to evaluate two soybean nematicide seed treatments, ILEVO (fluopyram) and Saltro (pydiflumetofen), compared to non-treated plain seed, for stand emergence, control of SCN, and yield differences. Both seed treatments increased speed and percent of germination. Saltro treated plants yielded the highest, at 36.4 bushels per acre, but there were no statistically significant yield differences among treatments. In this trial, Saltro was the most effective at reducing cysts per plant and had the lowest numerical SCN populations at the end of the season. Further replications of this experiment will be conducted in 2021 to confirm preliminary results.