Interveinal chlorosis (yellowing between leaf veins) and leaf necrosis (tissue death) of soybean foliage, exacerbated by the presence of Soybean Cyst Nematode in the same field, has been reported to cause significant yield losses in soybeans globally. Similar infections, in conjunction with SCN, were identified on a soybean variety at Langdon Research Extension Center (LREC). Most of the samples were confirmed to be Brown Stem Rot (BSR) infections through molecular analysis. The symptoms of interveinal chlorosis and tissue death led to a decline in crop growth, and a significant reduction in yield was recorded at LREC over the past two seasons. Soil samples collected from the infected field tested positive for the presence of Soybean Cyst Nematode (SCN), and BSR (Phialophora gregata) was identified as one of the major pathogens causing interveinal chlorosis and tissue death in soybean. Among the seed treatments tested this summer, the seed treatment Trunemco™ (Bacillus amyloliquefaciens + CIS-Jasmone) showed the lowest normalized disease index (NDI) and the highest yield compared to six other seed treatments and a non-treated check. The continuation of this research for two more years holds the promise of adding a management option to combat the interveinal chlorosis caused by the combination of BSR and SCN.