PRE herbicides are essential components of a soybean weed management program, even when planting occurs earlier than traditional. However, the potential for soybean injury from PRE herbicides can be increased in early-planted systems. Cold, wet soil conditions can delay soybean seed germination and prolong the duration of soybean emergence, thereby increasing the duration of exposure to the PRE herbicides. These conditions also reduce the soybean plant’s ability to rapidly metabolize the herbicide, further increasing the potential for injury. Anecdotal conversations with early soybean planting practitioners have revealed some general reluctance to use certain herbicide chemistry classes for fear of enhanced soybean injury. Our previous research included only one commercial PRE herbicide because the focus of that research was to establish weed management concepts. This proposed research will take the next step in understanding weed management in early-planted soybean by investigating soybean injury potential from several commercially available PRE herbicides. Results of this research will better inform soybean producers about which herbicides or herbicide classes they might want to avoid in early-planted soybean scenarios. The 2025 growing season will be the second year of this two-year research project.