Greenhouse gas emissions from upland crops are difficult to abate because they are dominated by nitrous oxide (N2O) production from soil processes. Using a review of peer-reviewed literature, we show that annual rotation of corn with soybean leads to a 50% reduction in 2-year emissions compared to continuous corn. Nevertheless, emissions from the corn-soybean rotation remain substantial and, despite optimum N fertilizer management in corn the corn phase of the rotation, approximately 40% of the emissions occur during the soybean phase the rotation. Using cropping systems models, we developed a strategy that combines cover crop management and earlier planting of longer growth soybean genetics to reduce emissions from soybean production by 33%. Earlier planting and cover crops reduce fallow periods that are critical sources of emissions. These practices, which complement N fertilizer management in maize, are widely accessible and represent an immediate opportunity to reduce emissions from soybean production. We recommend three key steps towards decarbonizing US crop production: 1) rotate corn with soybean; 2) optimize N fertilizer in corn; 3) reduce fallows in the soybean phase of the rotation.