This project will address farmer/applicator questions regarding best practices to manage large pigweeds (Palmer amaranth and waterhemp) in Enlist soybeans. Specifically, we will 1) compare sequential applications of Liberty and Enlist One in small plots, 2) evaluate Liberty efficacy in a range of temperature and humidity conditions in the field, 3) compare herbicide treatments in on-farm field trial, and 4) collect weed seed samples to screen for herbicide resistance.