Soybean cyst nematode (SCN) is a major soybean pathogen causing annual yield losses estimated in excess of $1.2 billion. The presence of SCN in a field, but most importantly, the SCN numbers, will determine the best management strategy. We propose this research because we are studying many aspects of the biology of the most important pathogen in soybean and continuing to evaluate best integrated management strategies that will help soybean growers in Ohio minimize yield losses due to SCN. The project is designed to help us understand the relationship between SCN, soil texture, soil health parameters and soybean production (objective 1); the SCN interaction with other plant species (objective 2) and the effect of nematode-protectant seed treatments and soybean performance with resistance from PI88788 and Peking in SCN infested fields. The results of this project will provide immediate and long-term benefits to soybean producers and researchers.