Field experiments will be conducted in a grower’s field infested with glyphosate-resistant Palmer amaranth near Carleton in Thayer County, Nebraska. Treatments will be arranged in a randomized complete block design (RCBD) with an augmented 2 x 12 factorial treatment arrangement with four replications. The augmented factorial treatment arrangement will include cereal rye termination timing (2 weeks before and after planting soybean) and 12 treatments, including three pre-emergence herbicides (Authority Supreme, Fierce MTZ, and Zidua PRO), post-emergence herbicides (Roundup PowerMax, XtendiMax), and a non-treated control, a weed-free control but cereal rye present, and a weed free and cereal rye free control. Palmer amaranth control, density and biomass will be measured and effect on soil health, yield, and cost-benefit ratio of each treatment will be calculated. An extension field day will be organized at the research site to demonstrate the results of the project to soybean growers and results will be presented during extension meetings and will be published in Crop Watch and NebGuide.