High-yielding soybeans fields producing more than 60 bu/acre require excellent management and are exporting more nutrients than average-yielding fields. There is uncertainty if the current recommendations of phosphorus (P) and potassium (K) fertilizers for North Carolina are adequate for high-yielding fields. We applied rates of P and K on two on-farm, high-yielding soybean fields and on three long-term trials at Research Stations of North Carolina. We did not observe an increase in crop yields when the P-index and K-index were higher than 50 at any of the trials. This means the current recommendations presented in the “Crop Fertilization Manual” are adequate even for high-yielding fields. The findings of this study show that our producers can keep using the current fertilizer recommendations, even in high-yielding fields, and they will not run short of nutrients. The results of this project will help our farmers to avoid unnecessary application of fertilizers, cut costs, and increase their profit.