No matter the herbicide tolerance, soybean varieties with high yield and good resistance or tolerance to major pests and with lower seed costs are essential to soybean profitability in southeast Missouri. Soybean cyst nematode (SCN), root knot nematode, reniform nematode, frogeye leaf spot, sudden death syndrome (SDS), stem canker, phytophthora root rot and charcoal rot are important diseases in Missouri. Resistant varieties are the most economical means to reduce yield losses to diseases.