The predicted outcome is that foliar fungicides will only provide a yield benefit to the varieties that are susceptible to frogeye leaf spot, and perhaps those that are moderately-resistant to frogeye leaf spot. For profitability purposes, yield potential of each variety will play a large role – i.e., if a susceptible variety has a larger yield potential than a resistant variety, then it could be more “profitable” to grow the susceptible variety and spray it with an effective fungicide vs. planting the resistant variety with no fungicide (or vice-versa). Since this project will rely on “natural” disease pressure and rainfall, it is possible that disease pressure could be limited in some locations. Based on the level of frogeye leaf spot severity at many of the UK Soybean Variety Performance Tests in the 2016 season, the potential for frogeye leaf spot to occur at these locations is good.