Due to rapid evolution and spread of herbicide resistance in Palmer amaranth and gradual decrease in the number of effective herbicides in soybean to control this problem weed, results of this study will help growers to make a robust herbicide program in Roundup Ready and Liberty Link soybeans, as well as in the new herbicide-tolerant cultivar such as Roundup Ready 2 Xtend, Enlist, and Balance GT.