Soybean cyst nematodes (SCN) remain the most serious disease threat to soybeans in Kentucky. In previous studies, a strobilurin foliar fungicide applied at the early pod stage (R3) could limit yield losses caused by SCN. In these studies, yields were increased by 3-5 bu/ac when Headline (a strobilurin fungicide) was applied in the absence of fungal disease pressure and SCN pressure was moderate. The hypothesis being tested is whether applying a strobilurin fungicide could help a SCN-stressed crop compensate for damage, resulting in higher yields compared to when a fungicide is not applied.