The recent acquisition of new, state-of-the-art instrumentation has allowed us to rapidly and dramatically enhance our understanding of the full range of defense metabolites made by soybean. In the past year, many new metabolites, previously unknown to soybean, were discovered and have led to surprising new insights into the genes and defense pathways potentially involved in pest resistance. In the work proposed here, we wish to capitalize on this new knowledge and instrumentation to determine the key soybean metabolites that provide resistance to powdery mildew and the soybean aphid, two very important emerging soybean pests. Identification of the key defense metabolites should allow...